Background/Introduction: The correlation between percutaneous coronary intervention (PCI) and abdominal ascites or pleural effusion drainage of heart failure with reduced ejection fraction (HFrEF) patients, is not well studied. Purpose: We aimed to identify the association between PCI and abdominal ascites o thoracic drainage incidence of HFrEF patients enrolled in a Middle Eastern single centre heart failure registry. Methods: We performed subgroup analysis of prospectively collected data of 174 consecutive HFrEF patients hospitalized over 12month period. Results: Ultrasound guided drainage was performed more frequently in ischemic compared to nonischemic cardiomyopathy patients (8% vs. 0.9%; P = 0.024). Among the 23 (13%) PCI patients, there was no need for abdominal or thoracic drainage, compared to 151 (67%) nonPCI patients (P = < 0.0001). Females had higher statistically insignificant drainage incidence compared to males (10% vs. 4%; P = 0.261). Conclusion: PCI is associated with significant reduction of drainage requirement of HFrEF patients. Ischemic cardiomyopathy, female gender and nonPCI feasible subgroups were at high risk for abdominal or thoracic drainage requirement