Staff Members - Benha University
Correlation between low body mass index and clinical safety outcome measures of patients with congestive heart failure: perspective of a singlecentre, prospective pilot study
European Journal of Heart Failure Abstracts Supplement • 2016
Publication Information
Authors
S Khaled, L Faour, K Salem
Keywords
Not Available
Journal
European Journal of Heart Failure Abstracts Supplement
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Shereen Mohamed Khalid_Abstract_P1438.pdf
Abstract
Background/Introduction: The correlation between low body mass index (BMI) and congestive heart failure
(obesity paradox) has been described in the literature; however, the association between BMI and clinical
outcome measures is not well characterized. Purpose: This study aimed to describe the correlation among BMI
and myocardial infarction (MI)/cerebrovascular accident (CVA)/mortality composite outcome, combined
infection/bleeding and combined CVA/transient ischaemic attacks (TIA)/unexplained syncope outcome
measures of patients with heart failure with reduced ejection fraction (HFrEF). Methods: Retrospective
analysis of prospectively collected data of a single centre heart failure registry in Saudi Arabia. Results: Of 167
patients with HFrEF, 41 (25%) had BMI of ≤24 kg/m2. The low BMI group had higher composite
MI/CVA/mortality (19% vs 3%; P = 0.014) and composite infection/bleeding (12% vs 19%; P = 0.016) rates
compared with those with BMI of>24 kg/m2. Moreover, the study revealed that lower the BMI, higher the
CVA/TIA/unexplained syncope (23.9, 5.5 vs 28.7, 6.2; P = 0.01), higher the composite MI/CVA/mortality
(26.4, 5.6 vs 29, 6.3; P = 0.014) and lower the combined infection/bleeding (27.7, 5.8 vs 31.3, 7.3; P = 0.01)
rates. Conclusion: Patients with HFrEF having BMI of ≤24 kg/m2 had a higher incidence of
MI/CVA/mortality, higher combined CVA/TIA/unexplained syncope incidence and lower combined incidence
of bleeding/infection compared with those having BMI of>24 kg/m2.
(obesity paradox) has been described in the literature; however, the association between BMI and clinical
outcome measures is not well characterized. Purpose: This study aimed to describe the correlation among BMI
and myocardial infarction (MI)/cerebrovascular accident (CVA)/mortality composite outcome, combined
infection/bleeding and combined CVA/transient ischaemic attacks (TIA)/unexplained syncope outcome
measures of patients with heart failure with reduced ejection fraction (HFrEF). Methods: Retrospective
analysis of prospectively collected data of a single centre heart failure registry in Saudi Arabia. Results: Of 167
patients with HFrEF, 41 (25%) had BMI of ≤24 kg/m2. The low BMI group had higher composite
MI/CVA/mortality (19% vs 3%; P = 0.014) and composite infection/bleeding (12% vs 19%; P = 0.016) rates
compared with those with BMI of>24 kg/m2. Moreover, the study revealed that lower the BMI, higher the
CVA/TIA/unexplained syncope (23.9, 5.5 vs 28.7, 6.2; P = 0.01), higher the composite MI/CVA/mortality
(26.4, 5.6 vs 29, 6.3; P = 0.014) and lower the combined infection/bleeding (27.7, 5.8 vs 31.3, 7.3; P = 0.01)
rates. Conclusion: Patients with HFrEF having BMI of ≤24 kg/m2 had a higher incidence of
MI/CVA/mortality, higher combined CVA/TIA/unexplained syncope incidence and lower combined incidence
of bleeding/infection compared with those having BMI of>24 kg/m2.