Background: Patients with multi-vessel coronary artery disease (MVD) compared to single-vessel coronary artery disease (CAD) have more comorbidities, cardiovascular risks, higher prevalence of left ventricular dysfunction and hence poor in-hospital outcomes. Our aim is to analyze MVD-AMI patients regarding demographics, clinical characteristics, management and short- term outcomes in a tertiary care center located in specific region with advantage of variable clinical backgrounds of its admitted patients. Result: This is a retrospective analysis of the prospective collected data registry, single center study reviewing the clinical details and hospital outcome measures of AMI patients referred to our center for early revascularization from 2016 to 2019. Out of 3041 of patients presented with AMI, 491(16%) had MVD on coronary angiogram. MVD-AMI patients were significantly older at age, had higher prevalence of DM, HTN and history of ischemic heart disease compared to non- MVD –AMI group (P