Background Intracerebral hemorrhage is the most devastating form of stroke. Location and baseline hematoma volume are strong predictors of mortality. Expansion of the initial hematoma is a further marker of poor prognosis. Several risk factors for hematoma expansion (HE) have to be identified. Objectives The objectives of this study were to detect the incidence of HE and to study its predictors. Patients and methods 145 patients underwent this study by analyzing demographic factors and vascular risk factors such as hypertension, diabetes mellitus, and oral anticoagulant intake, as well as clinical factors using National Institutes of Health Stroke Scale (NIHSS) and radiological factors using computed tomography brain imaging. Results In this study, HE occurred in 55 (37.93%) patients. Expansion occurred in 45.45% of hypertensive patients, 55.56% of oral anticoagulant intake patients, 45.83% of low cholesterol level patients, 3.64% of diabetic patients, 85.71% of patients with high NIHSS, 35.71% of patients older than 60 years, 20% of patients with atrial fibrillation, and 22.2% of renal patients. Conclusion Warfarin intake, hypertension, low cholesterol, normal blood glucose, lack of blood disease, and high NIHSS are the main predictors of HE.