Background. Genetic predisposition plays a crucial role in susceptibility to vitiligo. Recent progress is providing key insights into the manner in which individual susceptibility genes contribute to disease pathogenesis and clinical types. T cell and relatedcytokines have been proved to contribute in vitiligo pathophysiology. Objectives. In the present study, we assessed the association of TNF-α (-308 G/A), IL10 (-1082 A/G) and FOXP3 (-3279 A/C) genes polymorphisms among a sample of Egyptian patients with generalized vitiligo. Methods. We genotyped 150 unrelated patients with generalized vitiligo vulgaris and 200 apparently healthy unrelated control individuals for TNF-α (-308 G/A), IL10 (-1082 A/G) and FOXP3 (-3279 A/C) genes polymorphisms by ARMS-PCR and PCR-SSP. Results. We found that AA, GA genotypes and A allele in TNF-α (G-308A) and GG, AG genotypes and G allele in IL-10 (G-1082A) polymorphisms were significantly associated with generalized vitiligo patients. Conclusion. Results of the present study suggested the possible involvement of the TNF-α (-308) A and IL-10 (-1082) G but not FOXP3(-3279 A/C) alleles as a genetic risk factor for generalized vitiligo among Egyptian patients.