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TNF-α (-308 G/A) and IL10 (-1082 A/G) but not FOXP3 (-3279 A/C) genes polymorphisms are associated with generalized vitiligo: an Egyptian study
Clinical Dermatology • 2019
Publication Information
Authors
Abdel Aziz Eltaweel1Amany Mustafa1Ola El-Shimi2Abd El Rahman S, Mustafa A, El-Shimi O, Abd El Rahman S and Fawzy ImanIman Fawzy4
Keywords
generalized vitiligo; genetic susceptibility;
Egypt; TNF-alpha; IL-10
Journal
Clinical Dermatology
Publisher
Roma: CIC Edizioni Internazionali
Volume
7
Issue
1
Pages
30-35
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background. Genetic predisposition plays a crucial
role in susceptibility to vitiligo. Recent progress is
providing key insights into the manner in which
individual susceptibility genes contribute to disease
pathogenesis and clinical types. T cell and relatedcytokines
have been proved to contribute in vitiligo
pathophysiology.
Objectives. In the present study, we assessed the
association of TNF-α (-308 G/A), IL10 (-1082 A/G)
and FOXP3 (-3279 A/C) genes polymorphisms
among a sample of Egyptian patients with generalized
vitiligo.
Methods. We genotyped 150 unrelated patients with
generalized vitiligo vulgaris and 200 apparently
healthy unrelated control individuals for TNF-α (-308
G/A), IL10 (-1082 A/G) and FOXP3 (-3279 A/C) genes
polymorphisms by ARMS-PCR and PCR-SSP.
Results. We found that AA, GA genotypes and A
allele in TNF-α (G-308A) and GG, AG genotypes and
G allele in IL-10 (G-1082A) polymorphisms were significantly
associated with generalized vitiligo
patients.
Conclusion. Results of the present study suggested
the possible involvement of the TNF-α (-308) A and IL-10 (-1082) G but not FOXP3(-3279 A/C) alleles as a
genetic risk factor for generalized vitiligo among
Egyptian patients.
role in susceptibility to vitiligo. Recent progress is
providing key insights into the manner in which
individual susceptibility genes contribute to disease
pathogenesis and clinical types. T cell and relatedcytokines
have been proved to contribute in vitiligo
pathophysiology.
Objectives. In the present study, we assessed the
association of TNF-α (-308 G/A), IL10 (-1082 A/G)
and FOXP3 (-3279 A/C) genes polymorphisms
among a sample of Egyptian patients with generalized
vitiligo.
Methods. We genotyped 150 unrelated patients with
generalized vitiligo vulgaris and 200 apparently
healthy unrelated control individuals for TNF-α (-308
G/A), IL10 (-1082 A/G) and FOXP3 (-3279 A/C) genes
polymorphisms by ARMS-PCR and PCR-SSP.
Results. We found that AA, GA genotypes and A
allele in TNF-α (G-308A) and GG, AG genotypes and
G allele in IL-10 (G-1082A) polymorphisms were significantly
associated with generalized vitiligo
patients.
Conclusion. Results of the present study suggested
the possible involvement of the TNF-α (-308) A and IL-10 (-1082) G but not FOXP3(-3279 A/C) alleles as a
genetic risk factor for generalized vitiligo among
Egyptian patients.