Sickle cell disease is an autosomal recessive disease that causes considerable morbidity and mortality. The aim of the study is to evaluate the effect of self-care management program on pain and fatigue in sickle cell children. Research design: A quasi-experimental design was used to complete this study. Settings: The study was conducted at the hematology department at Benha Specialized Pediatric Hospital and Benha University Hospital at Benha City. Sample: A purposive sample of 100 children with sickle cell anemia was included from the above mentioned settings. Fulfilled the following criteria aged from 9-18 years. Tools: Five tools were used to collect the study data: Tool I: A structured interviewing questionnaire format. It was developed by the researchers and includes three parts to collect data: Part 1: Personal characteristics of mothers. Part 2: Personal characteristics and illness history data of the studied children. Part 3: Children’ knowledge regarding sickle cell anemia Tool II: Pediatric pain coping strategies scale. Tool III: Pain assessment scale (Numeric Rating Scale). Tool IV: Assessment of Fatigue scale in Pediatric patient aged 7-18 for Parents. Tool V: Children self-care practices to avoid pain and fatigue. Results: Overall the results have a highly statistically significant differences (P