Introduction Dysregulation of aquaporins (AQPs) is thought
to be involved in urothelial carcinogenesis and progression.
Angiogenesis is necessary for the growth and subsequent
metastasis of transitional cell carcinoma. However, whether
there is a positive association in transitional cell carcinoma has
not yet been established. This research was conducted to
analyze the expression of AQP3 and vascular endothelial growth
factor (VEGF) in transitional cell carcinoma with a view toward its
development and progression and to correlate them with
clinicopathological parameters.
Patients and methods This is a retrospective, selected,
controlled study carried on 55 pure transitional cell carcinoma
cases from January 2010 to December 2017 to assess the
immunohistochemical expression of the AQP3 and VEGF and
to correlate them with various clinicopathological parameters.
Results AQP3 expression showed positive expression in
normal urothelium (100%), 90%in carcinoma in situ (CIS) cases,
whereas in transitional cell carcinoma, it was detected in 52.7%
of cases. AQP3 expression is lower in transitional cell carcinoma
cases than CIS and normal mucosa (P