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Comparative Immunohistochemical Study of BCL2 and CD138 In Odontogenic Keratocyst, Ameloblastoma and Radicular Cyst, Considering WHO Classification
Egyptian Journal Of Pathology • 2020
Publication Information
Authors
Rania G. Roshdy (MD) & Sarah N. Nasi f(MD)
Keywords
Not Available
Journal
Egyptian Journal Of Pathology
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
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publication.type
Local
Paper Link
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Supplementary Materials
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Abstract
Background: Odontogenic keratocyst (OKC) is one of odontogenic lesions which has been recently classified as a developmental cyst in last WHO odotogenic classification 2017, despite of its clinical aggressiveness and relative rate of recurrence.
Aim : The aim of the current work was to assess and compare Odontogenic keratocyst with both ameloblastoma (AM) and radicular cyst (RC) in relation to immunohistochemical expression of BCl2 and CD138 .
Method: This is a retrospective study included 15 cases of Odontogenic keratocyst, 20 cases of ameloblastoma, and 15 cases of radicular cyst. Immunohistochemical technique was applied to detect and compare BCL2 & CD138 expression in these lesions.
Results: For BCL2, (86.6 %) of odontogenic keratocyst cases and all studied ameloblastoma cases (100%) were positive for bcl-2 without significant statistically correlation (p>0.05).At the same time odontogenic keratocyst were significantly correlated with radicular cysts which were completely negative to Bcl-2 (
Aim : The aim of the current work was to assess and compare Odontogenic keratocyst with both ameloblastoma (AM) and radicular cyst (RC) in relation to immunohistochemical expression of BCl2 and CD138 .
Method: This is a retrospective study included 15 cases of Odontogenic keratocyst, 20 cases of ameloblastoma, and 15 cases of radicular cyst. Immunohistochemical technique was applied to detect and compare BCL2 & CD138 expression in these lesions.
Results: For BCL2, (86.6 %) of odontogenic keratocyst cases and all studied ameloblastoma cases (100%) were positive for bcl-2 without significant statistically correlation (p>0.05).At the same time odontogenic keratocyst were significantly correlated with radicular cysts which were completely negative to Bcl-2 (