Background: Hirsutism is a common clinical condition encountered in day‐to‐day practice. The androgenic causes account for more than 80% of these patients and include polycystic ovary syndrome (PCOS), which affects about 70%‐80% of hirsute women. The second most common cause is idiopathic hirsutism. Omentin‐1 is an adipokine mainly produced by visceral adipose tissue. Aim: The current study aimed at evaluating omentin‐1 levels in hirsute females with PCOS and in idiopathic hirsutism. Patients and Methods: Eighty‐five females were included in this study. They were classified into three groups: thirty hirsute patients with PCOS, thirty females with idiopathic hirsutism, and twenty‐five healthy control females. The participants were subjected to history taking, physical and dermatological examination. A gynecological history and radiological examination of the ovary also were done. Serum testosterone and omentin‐1 were measured by ELISA. Results: Serum testosterone was statistically elevated in PCOS than other groups. Serum omentin‐1 in females with idiopathic hirsutism was statistically significantly higher than control and PCOS. There was a significant inverse correlation between serum testosterone level and serum omentin‐1 level. Conclusion: Omentin‐1 may be involved in the pathogenic process of hirsutism.