Objective: To examine the predictive efficacy of CHA2DS2-VASc score in predicting CAD severity with respect to SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery) and GLS in patients with Acute Myocardial Infarction (AMI) severity. Patients with atrial fibrillation (AF) are assessed for thrombotic risk using the CHA2DS2-VASc score. In patients with an acute coronary syndrome, regardless of AF, was recently demonstrated to predict severe unfavourable clinical outcomes. Methods: ACS patients who had had coronary angiography were separated into three groups based on their SYNTAX scores and a total of 577 individuals were included in this study retrospectively (low, intermediate, and high). Each patient's CHA2DS2-VASc score was computed. The participants were divided into three groups for the study. Zero, one, two, three, or four.