Proanthocyanidins, also known as condensed tannins, can prevent obesity induced oxidative stress
damage in the liver. This study aimed to evaluate the protective effect of Proanthocyanidins on obesity
induced oxidative stress and biochemical abnormalities in male rats. Forty-eight male albino rats were
divided into three equal groups. Group I (control normal): rats received normal diet. Group II (Obesity):
rats received high fat diet (HFD). Group III (Obesity+ Proanthocyanidins): rats received
Proanthocyanidins (50 mg/kg.b.wt.) orally for two months after induction of obesity. The obtained
results showed significant increase in serum insulin, lipids profile (total cholesterol and
triacylglycerols) concentrations, liver L-MDA in addition to up regulation of leptin and Nuclear factor
kappa B (NF-κB) gene expression level in liver tissues of obese rats. However, liver catalase activity
and GSH concentration were markedly decreased. These results suggested that, Proanthocyanidins
treatment exerts a protective effect on obesity by reduction of oxidative stress, inflammation and
hyperlipidemia in rats through free radical scavenging and anti-inflammatory activities as well as
regenerating endogenous antioxidant defense system mechanisms.