The present study was conducted to evaluate the safety and / or the toxicity of acute dual propolis and ginger treatment. Different doses 1, 2, 3, 4 and 5 g/kg b.wt (w/w) of the dual composite were administrated as an aqueous solution via an oral gavage to female albino rats. No adverse effects or mortality were observed during the 72-hrs observation period. In addition, necropsy examination indicated no abnormalities in the main organs after administration of any dose. Further, histopathological, hematological indices (hemoglobin, red blood cells, hematocrite, and white blood cells) and plasma parameters included Alanine amino transferase (ALT) and aspartate amino transferase (AST) , total protein (TP) total cholesterol, triglycerides (TG), creatinine and urea, malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were assessed in the plasma of all rats after treatment with the limited oral dose 5 g/kg b.wt (w/w). There were no changes in histological architectures of brain and liver hematological and plasma chemistry values of the examined parameters. Collectively together, the hematological, biochemical and histological studies verified that oral dual administration of propolis and ginger in female rats was quite safe up to the limited dose used and did not cause any toxic symptoms or changes.