Diabetes mellitus is a global health, widespread disease, that affects many millions of people allover the world, which consider a serious health problem. Hyperglycemia which consider the main symptoms of diabetes can lead to diabetic complication which is considered the leading cause of morbidity and mortality. Oxidative stress is increased in DM, due to increased level production of oxygen free radicals and decreased the level of the antioxidant defense mechanisms. Natural products are in a particular interest, as they are used to perform important biological functions. Natural compounds possibly to be appropriate alternatives for diabetes therapy. They can decrease the risk factor of many diseases, they can consume in Large amount daily without any side effect as synthetic drugs. Alpha-lipoic acid is a natural substance antioxidant. It is the main cofactor for energy production in the mitochondria. Alpha-lipoic acid has been shown to reduce symptoms of the patient suffering from diabetes. This review article aimed to elucidate the antidiabetic activity of Alpha-lipoic acid as well as showed their merit that makes them ideal for antidiabetic treatment