Hyperlipidemia is a known risk factor for the development of cardiovascular disease including atherosclerosis. This study was designed to evaluate the effect of oral intake ofTaurine (TU) on lipid profile, glucose, insulin, insulin resistance (HOMA) in serum and anti-oxidant enzyme activities catalase (CAT), superoxide dismutase (SOD), reduced glutathione(GSH) and L-MDA, in liver of high fat diet induced hyperlipidemia in male albino rats by feeding high fat diet.One hundredmale albino rats were divided into four equal groups of 25 rats each Group Ι :( Control normal group): rats fed normal diet. Group II: (hyperlipidemic group): rats fed high fat diet (HFD) and administered no drugs. Group III (HFD +TU): rats fed HFD and administeredtaurine once daily (500 mg/kgb.wt./day, orally) for 8 weeks. Group IV (control positive): rats received the control normal diet andadministered taurine once daily (500mg/kg b.wt. Orally) for 8 weeks. Blood samples were collected after 3, 6 and8 weeks from the onset of taurine administration for determination of serum glucose, insulin, insulin resistance, total cholesterol(TC), triacylglycerol(TAG), phospholipids, Low density lipoprotein-cholesterol (LDL-c), Very low density lipoprotein-cholesterol (VLDL-c) and High density lipoprotein-cholesterol (HDL-c) levels in addition to antioxidant enzymes activities in liver (CAT),(SOD),(GSH) and MDA concentration in liver tissue .the obtained results revealed that, rats fedHFD exhibited significant elevation of serum TC, TAG, ( VLDL-C), MDA with marked decreased in serum phospholipids concentrations compared to rats fed normal diet. Meanwhile, administration of taurine to HFD-fed rats tended to prevent hyperglycemia, improve dyslipidemia and other changes relevant to high fat diet mainly through improving activities of anti-oxidant enzyme and scavenging free radical and enhancement cholesterol metabolism to convert it to bile salts, which consequently reduce lipid profile in serum and insulin resistance. These results suggest that, taurine is effective in improving the obesity and coronary heart disease.