Cinnamon extracts are widely used Arabian and Asian countries as herbal and medical plant. The cinnamon has active substances which have in vivo hypoglycemic activity and probably improve insulin sensitivity. Up till now the molecular mechanism of CE on genes expression is not yet determined. In this study, we examined the effect of CE (200 mg/kg body weight) in diabetic Wistar rats by testing its effect on genes related to lipids and glucose metabolism. In induced diabetic experiments, CE treatment normalized significantly (p< 0.05) the increase in lipid profiles and glucose levels occurred in diabetic rats. In parallel, CE lowered glucose levels through the increase in insulin secretion ji-om still working 0 cells. The antidiabetic action of CE was confirmed as CE treated diabetic rats showed an increase in the mRNA expression of leptin, PPAR- 0 and adiponectin. In conclusion, CE has antidiabetic and insulin-mimetic actions through the regulation ofgenes related to lipid and glucose metabolism.