Background: Currently, ultrasound-guided percutaneous biopsies, abdominal abscesses evacuation, cyst and fluid aspiration are standard diagnostic techniques. This research purposed to clarify role of ultrasound guided evacuation and intra-abdominal fluid collections aspiration. Methods: This cohort prospective research was conducted on 50 intra-abdominal fluid collections individuals who had ultrasound-guided percutaneous evacuation. The collections were discovered and targeted by ultrasound or guided percutaneous needle aspiration, and a safe evacuation path that protected key anatomic structures was devised. All participants underwent exhaustive patient history, clinical and general examinations and lab investigations and radio diagnostic imaging. Results: Regarding the location of collection, it was intraperitoneal in 33(66%) patients and retroperitoneal in 17(34%). The nature of collection was liver abscess in 25(50%) patients, peripancreatic collection in 10 (20%) patients, GB perforation in 8 (16%) patients and appendicular abscess in 7 (14%) patients. Nature of fluid was unilocular in 26 (52%) patients and multilocular in 24 (48%) patients. The volume drainage ranged from 476-775 ml with a mean of 622.74±84.39 ml. Catheter was the treatment option in 29 (58%) patients and Puncture was the treatment option in 21(42%) patients. The hospital stay was with a median of 2.5 days. Conclusions: US-guided evacuation is an effective treatment for intra-abdominal collections and has become the therapeutic option for a broad range of intra-abdominal collections. It is advantageous to avoid or postpone a big operation.