Two field experiments were carried out during the two successive Summer seasons of 2017and 2018 at the experimental farm of the Faculty of Agriculture, Moshtohor, Benha University to investigate the effect of two propagation methods (cutting or mini tubers), four sources of N fertilizers in either organic or mineral forms (100% mineral N fertilizer (as recommended dose120kg N/fed), 50% mineral + 50% organic, 25% mineral + 75% organic and 100% organic-N fertilizers) combined with three soil addition with effective microorganisms (EM) at 10%, seaweed extract at 1% and yeast extract at 10% as well as their combinations on vegetative growth characters, chemical constituents of plant foliage yield, physical and chemical quality of produced potato (Solanum tuberosum L.) cv. Spunta. This experiment was set up in a split split-plot design. Obtained results showed that planting potato by cutting tubers then fertilized with 50% of the recommended (N-fertilizers in the mineral form (ammonium nitrate 33% N) and 50% in organic form (chicken manure) combined with the soil addition of seaweed extract at 1% three times significantly surpassed mostly all studied vegetative growth parameters, chemical constituents of plant foliage, total yield per plant or feddan and the best physical and chemical quality of produced tubers during both seasons of study