The impact effects of electromagnetic radiation (EMR) on human health have become a main subject of research interest among scientists due to their rapid increase in use. Therefore, the present study aimed to investigate the possibility of hepatotoxicity associated with exposure of male mice to mobile phone radiation, MPR, (900 MHz) for 8 weeks, and to evaluate the hepatoprotective potentials of some famous historical architectural shapes. Thirty-six (36) Swiss Albino male mice were randomly divided into 6 groups (n = 6). Group 1 served as a control without a mobile phone and housed in a traditional cage, group 2 housed in a traditional cage, and the groups 3-6 housed in different architectural shapes. Exposure of mice (2-6 groups) to MPR led to a significant increment (P