Background: Climacteric Phase represents a critical life stage encompassing a range of physiological and psychosocial changes that require adaptions to optimize health and functioning. Aim of this study was to evaluate the effect of applying an Educational program on self-efficacy of Women at Climacteric Period: utilization PRECEDE-PROCEED model. Design: Quasi-experimental equivalent study. Sitting: Administrative Building of Benha University hospitals. Sample: a purposive sample was selected according to inclusion and exclusion criteria. The sample consisted of two groups (Study group comprising 55 Climacteric women who received the educational intervention and control group comprising 54 Climacteric women who didn’t not receive). Tools: Two tools of data collection: Tool I: a structured interviewing questionnaire sheet , PRECEDE-PROCEED model (predisposing "knowledge and attitude", reinforcing and enabling factors) and Tool II: self-efficacy scale Results: there was a highly statistically significant difference was observed in predisposing factors, reinforcing factors, enabling factors and self-efficacy of the study group compared with the control group after six months of PRECEDE - PROCEED model application (p < 0.001). Conclusion: The PRECEDE - PROCEED model provided an excellent framework for health intervention programs especially in enhancing self-efficacy. Recommendations: PRECEDE - PROCEED model must be applied in the process of education by considering all effective personal, environmental, social and supportive factors for future health promotion program development for women.