antenatal women knowledge regarding minor and its related management is essential to safeguard pregnant women own health. Aim: the present study was to evaluate the effect of utilization of self-care practice guideline on relieving minor discomfort (ailments) among new pregnant women. Setting: the current study was conducted at the antenatal clinic at Benha University Hospital. Research Design: A Quasi-experimental design was used. Sample: Purposive sample included 240 primigravida women in the first trimester of pregnancy were recruited in the present study. Data collection: A structured interviewing questionnaire, knowledge assessment sheet and self-care reported practice assessment tool were used to collect the required data. Results: the present study revealed that, there was a highly statistically significant improvement knowledge mean score, knowledge mean score was increased from 11.5 to 54.59 at post intervention .In addition self-care reported practice was satisfactory improved, as practice mean score was increased from 7.84 to 51.35 at post intervention phase and there was a highly positive association between women knowledge and practice score. Conclusion: self-care practice guideline is effectively improving primigravida women knowledge and self-care practice regarding management of minor discomfort .Recommendation: self-care practice guideline regarding self-care management for minor discomfort is essentially recommended for pregnant women during antenatal visits