Context: Changes in everyday life have been rapid and drastic, with the virus surge outbreaks, the death rate escalating, and stringent steps to control the disease spread increasing across regions of the world. While significant attention has been paid to efforts to diagnose people with the coronavirus infection, recognizing the mental health needs of people affected by this pandemic has been ignored relatively. The psychological impact of the Coronavirus Disease 2019 (COVID-19) outbreak and lockdown measures on the Egyptian population are unknown. Aim: This study assesses levels of stress, anxiety, and depression symptoms in a population sample in the initial stage of the coronavirus pandemic (COVID-19) outbreak and explores its related potential risk factors. Methods: A cross-sectional design used to conduct the study on a convenience sample of 1010 subjects residing at Benha City, Qalyubiyah Governorate, Egypt. The tool utilized in this study consists of two parts: Self-administered questionnaire, which was designed to assess people's socio-demographic and family data, and Depression, Anxiety, and Stress Scale (DASS) that measure the symptoms of the emotional state of depression, anxiety, and stress. Results: The result reveals a mean of total stress scale as 15.44±3.62, mean of total anxiety scale as 13.56±3.74, and mean of total depression scale as 12.41±3.86. There was a high statistically significant positive correlation between anxiety, stress, and depression at pvalue