Drug addiction is a chronic disease that's often associated with other psychiatric disorders. Anxiety, depression and stress are the most common psychiatric problems in substance abuse which affect spiritual wellbeing. Aim of this study was to assess psychological problems and its effect on spiritual well-being among substance abuse patients . Research design: A descriptive correlational design was utilized to achieve the aim of the study. Setting: This study was conducted at outpatient clinic of Psychiatric & Mental Health Hospital in Benha City . Sample: A convenient sample of 40 Substance abuse patients who were enrolled in outpatient clinic. Tools: Three tools were utilized in this study. First tool divided into two parts. Part (1): Socio-demographic of substance abuse patients. Part (2): Previous clinical history of substance abuse. Second tool: Depression, anxiety and stress (DASS) scale to assess psychological problems of depression, anxiety and stress. Third tool: Spiritual well-being scale to measure levels of spiritual well-being for substance abuse patients. Results: More than half of the studied substance abuse patients had severe psychiatric problems (depression, anxiety & stress). Nearly three quarters of the studied substance abuse patients had low level of spiritual wellbeing. Conclusion: There was a highly statistical significant inverse correlation between spiritual well-being and psychological problems. Recommendation: Manipulate a program which enhances substance abuse patients to improve spiritual well-being with different life events.