Background: Autism defined by significant impairments in social interaction, deficits in communication and the presence of rigid behaviors and restricted interests. Aim: to evaluate the effect of Orem self-care model training on school-age and teenagers with a mild level of autism and their parent about self-care knowledge and practice. Design: One group quasi-experimental design was used in the current study. Setting: conducted at pediatric outpatient clinics of Benha University hospital. Sample: A purposive sample of all available school-age children and teenagers with a mild level of autism and their parents (n= 36). Tools: Data was collected through:/ (1) An interviewing questionnaire to assess self-care knowledge of school-age and teenagers with autism and their parent. (2) Orem self-care models and an observational checklist to assess self-care practice. Results: about two third of children was male (61.1%).More than half of parent stated obstacles toward self-care was inadequate training and teaching. Also, there was the improvement in parents' knowledge post-Orem self-care model implementation. Positive correlation coefficient between parent practice and their age and education level post-Orem self-care model implementation(r =0.40, p