Simulation training have been recommended for promoting intern nurses’ competence in maternal care delivery. Aim: The study aimed to evaluate the effect of simulation training on intern nurses’ competence and self-confidence regarding primary postpartum hemorrhage. Design: Quasi-experimental (pre-post design), was used to fulfill the aim of the study. Setting: The study was conducted in the clinical obstetrics skill lab and the classroom of faculty of Nursing at Benha University. Sample: A systematic random sample of (56) intern nurses. Tools: A self-administrated questionnaire, Creighton competency evaluation instrument, observational checklists regarding primary postpartum hemorrhage and satisfaction and self-confidence in learning scale. Results: There was a highly statistically significant improvement in relation to all competency domains related to assessment, communication, clinical-judgment and patient safety after simulation training compared to before simulation training (P ≤ 0.001). Moreover, there was a higher satisfaction and self-confidence after simulation training compared to before simulation training (P ≤ 0.001). Conclusion: Intern nurses will have higher level of competency and satisfaction and self-confidence after simulation training intervention than before. Recommendations: continuous simulation training programs and workshops should be planned on a regular basis to increase intern nurses’ knowledge and competent skills for achieving high nursing care and management of primary postpartum hemorrhage.