Background: Genetic variation at the insulin growth factor 2 binding protein 2 (IGF2BP2) gene has been associated with Type 2 Diabetes (T2DM) by genome-wide association studies. Aim of Study: To assess the genetic association of insulin growth factor 2 binding protein 2 (IGF2BP2) rs4402960 polymorphism with the development of type 2 diabetes mellitus in a sample from Egyptian patients. Patients and Methods: 50 subjects; 30 T2DM patients and 20 healthy controls. They were subjected to: History, clinical examination, measuring glycosylated hemoglobin, lipid profile and genotyping of IGF2BP2 (rs4402960) using Taqman-based allelic discrimination technique by Real-Time PCR. Results: There was significant statistical difference re-garding allele frequency of IGF2BP2 (rs4402960) as it exhib-ited an increased T allele frequency in the diabetic group while G allele was decreased compared to controls. The allelic association analysis confirmed a significant association with T2DM [OR=7.43, p=