Diazinon (DZN) is a widely used organophosphrus synthetic and acaricide widely used for agricultural and veterinary purposes. However, its human and animal exposure leads to hepatocardiotoxicity. Our experimental objective was to evaluate protective effects of Myrrh; Commiphora molmol or/ and ascorbic acid; vitamin C against DZN-induced hepatocardiotoxicity in healthy male white New Zealand rabbits (Oryctolagus cuniculus). DZN-treated animals revealed significant alterations in serum biochemical parameters related to hepatic and cardiac injuries. There was a significant increase in hepatic and cardiac lipid peroxidation and significant inhibition in tissue antioxidant biomarkers due to DZN intoxication. Both myrrh and vitamin C protect against DZN-induced serum as well as hepatic and cardiac tissue biochemical parameters when used alone or in combination along with DZN-intoxication. Furthermore, both myrrh and vitamin C produced synergetic hepatocardioprotective and antioxidant effects. Therefore, it could be concluded that myrrh and/or vitamin C administration able to minimize the toxic effects of DZN by its free radical-scavenging and potent antioxidant activity.