The nursing process is a problem-solving framework that enables the nursing staff to plan their care for (COVID-19) patients. Aim: this study aims to evaluate the effect of adapting (NANDA) nursing process as an approach of Care on nurses’ performance for COVID-19 Isolated patients. Design: Quasi experimental design was utilized to conduct this study. Setting: Isolation departments at Aswan University Hospital. Subjects: All nurses who are workers with (COVID-19) (17 males and 29 females) during the period from the beginning of April 1st 2020 to September 30th 2020. Tools :two tools used to collect the study data, Demographic data, nurses knowledge about COVID-19 and nursing' process application for nursing workers with (COVID-19) patients. Results: More than half of study sample’s age group between 26 < 30 years, females, no training on application of nursing process and half of them have institute education, three quarters of the study sample had satisfactory level of knowledge pre Adapting nursing process, while all study sample had satisfactory post application, highly significant results for total component of nursing process (assessment, diagnosis, planning, implementation, and evaluation) between pre/post Adapting application of nursing process for COVID-19 isolated patients. Also there are positive significant correlation between total component of nursing process and total knowledge post adapting application of nursing process for COVID-19 isolated patients. Conclusions: Results denotes that, improved level of nurses’ knowledge post caring for COVID-19 Isolated patients by using steps of nursing process with highly statistical significant deference’s for total components of nursing process pre/post application. Recommendations: The nursing staff and health care team must be continue educate on the application of the nursing process to emergency situation, nursing administration should develop effective departmental policies and procedures for staff nurses related to application (NANDA) nursing process as an approach of Care for COVID-19 Isolated patients.