Lower limb ischemia (LLI) associated with significant morbidity, mortality and activity impairment. LLI patients have poor baseline function, loss of functional status and ability to live independently with a risk of amputation if LL is not revascularized. This study aimed to investigate effect of lifestyle modification on functional ability and outcomes for patients with LLI. Design: Quasi-experimental design was utilized in this study. Setting: The study was carried out at the Vascular and Surgical departments at Benha University Hospital. During the period from the beginning of March 2019 till the beginning of March 2020. Sample: Purposive sample of 120 patients to be at the end of study period (Intervention group 60 & control group 60). Tools: Three tools used to collect the study data. These are structured interview questionnaire regarding the patients' demographic characteristics, medical data, assessment symptoms sheet and Patient knowledge regarding LLL, Lifestyle and Activiy of Daly living (ADL) checklist. Compliance Supervised exercised program Results: showed that there was highly statistically significant difference in term of increased knowledge level among the intervention group compared to controls, as well as a significantly improvement changes in symptoms assessment, a higher level of independence in performing ADL, besides, a higher mean score of supervised exercise program compliance among intervention group compared to controls. Conclusion: Implementing life style modification and supervised exercise program for patients with LLI was effective in improving their pain, pulse palpation odema redaction and knowledge about disease process. Also, performing ADL as well as its effectiveness in improving the functional ability and patient outcome among intervention group than in control group.