Two field experiments were conducted at the Experiment and Research Center, Fac. Agric., Moshtohor, Zagazig Univ., during 1995/96 and 1996/97 seasons. The aim of this study was to investigate the response of three wheat varieties (Sids 1, Sids3 and Giza167)to Agrispon treatments (foliar application with Agrispon vs. check treatment) and four N rates (zero,30,60 and 90 kg /fed). The results of the combined analysis showed that: Sids 3 variety gave the highest values of plant height, number of spikelets and kernels/spike, weight of kernels/spike, 1000- grain weight and biological, grain, and straw yields/fed campared with the other varieties. Sids1and Giza 167 recorded higher values of NUE compared with Sids 3. Plant height, number of spikelts and kernels/spike and biological, grain and straw yields/fed increased significantly by foliar application with Agrispon, whereas 1000–grain weight and NUE decreased by foliar application with Agrispon. The increase in N rate up to 90 kg N/ fed increased significantly plant height, spike length, number of spikelets and kernels/spike, weight of kernels/spike and biological, grain and straw yields/fed, whereas the increase in N rate reduced significantly NUE. Raising N rate from zero to 30, 60 and 90 Kg N/ fed increased grain yield/ fed by 11.44, 19.74 and 29.25%, respectively. Number of spikelets and kernels/spike, 1000-grain weight, biological and grain yields/fed and NUE were affected by the interaction between varieties and Agrispon treatments. Biological, grain and straw yields/fed and NUE were affected by the interaction between varieties and N rates. Also biological and straw yields/fed responded to the interaction between the three involved factors (varieties x Agrispon treatments x N rates). It could be concluded that under the conditions of the experiment, growing Sids 3 and application of Agrispon + 90 kg/fed is recommended.