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Correlation between serum ferritin and proteinuria as a marker of diabetic nephropathy stage in type 2 diabetic patients
Benha medical journal • 2022
Publication Information
Authors
Saddam AA Hassan, Mohamed A Mohamed, Nabil E Khattab, Samar Mohamed Atiaa, Abdelmoneim Ahmed Abdelmoneim
Keywords
Not Available
Journal
Benha medical journal
Publisher
Benha medical journal
Volume
38
Issue
3
Pages
865-880
publication.type
Local
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Background:
Increased iron reserves in the body have been linked to the development of type 2 diabetes, diabetic nephropathy, retinopathy, and vascular dysfunction. Serum ferritin has been related to the occurrence of CKD.
Aim of the study:
Aiming to look into the link between serum ferritin and proteinuria as a diabetic nephropathy marker in type 2 diabetic patients. subjects and methods: It involved 50 individuals of the same age and gender who were split into two groups: 25 type 2 diabetic patients with proteinuria and 25 apparently healthy volunteers (hospital personnel) with no history of diabetes who served as the control group. The Enzyme-linked immunosorbent assay (ELIZA) kit for quantitative detection of human serum ferritin was used to estimate serum ferritin.
Results:
In the current study, serum ferritin levels in diabetics with proteinuria showed a significant rise compared to the control group. (p < 0.001). In the comparative present study, the mean ± SD of diabetic patients with nephropathy, serum ferritin was 513.91±260.06 than that of control 133.42±186.66. The current study found a highly significant positive relationship between ferritin and 24h protein in diabetic patients with nephropathy(r=0.512, p=0.009), showing no significant positive association in the control group (r=0.02, p=0.94).
Conclusion:
serum ferritin can be considered an independent predicting marker of diabetic nephropathy as well as an excellent diagnostic marker for patients with clinical diabetic nephropathy.
Increased iron reserves in the body have been linked to the development of type 2 diabetes, diabetic nephropathy, retinopathy, and vascular dysfunction. Serum ferritin has been related to the occurrence of CKD.
Aim of the study:
Aiming to look into the link between serum ferritin and proteinuria as a diabetic nephropathy marker in type 2 diabetic patients. subjects and methods: It involved 50 individuals of the same age and gender who were split into two groups: 25 type 2 diabetic patients with proteinuria and 25 apparently healthy volunteers (hospital personnel) with no history of diabetes who served as the control group. The Enzyme-linked immunosorbent assay (ELIZA) kit for quantitative detection of human serum ferritin was used to estimate serum ferritin.
Results:
In the current study, serum ferritin levels in diabetics with proteinuria showed a significant rise compared to the control group. (p < 0.001). In the comparative present study, the mean ± SD of diabetic patients with nephropathy, serum ferritin was 513.91±260.06 than that of control 133.42±186.66. The current study found a highly significant positive relationship between ferritin and 24h protein in diabetic patients with nephropathy(r=0.512, p=0.009), showing no significant positive association in the control group (r=0.02, p=0.94).
Conclusion:
serum ferritin can be considered an independent predicting marker of diabetic nephropathy as well as an excellent diagnostic marker for patients with clinical diabetic nephropathy.