Background: Premenstrual dysphoric disorder is a clinical entity effecting 3-8% of women in their reproductive years, world wide imposing an enormous burden on women, their families and the health care system. Objectives: This study was designed to throw some light on the problem of PMDD among female student and some risk factors affecting it. Method: this study is a cross sectional short – term survey that was conducted on female students enrolled to different faculties of Benha University during the academic year 2006/2007. The studied group was drawn from the university student's house of females and included 612 students. The data are collected from participants with the help of self – administered questionnaire as well as personal interview. And physical examination. Results: The study revealed that about half (51.47%) of the studied group who had fulfilled the diagnostic criteria of PMDD. Urban students who are fulfilling the diagnostic criteria of PMDD were more (61.27%) than those from rural areas (38.73%). The percentage of students of PMDD who recorded the lowest degrees of a academia performance as accepted (28.25%) and Good (44.44%) were more than that recorded to other categories. More than half (52.06%) of students with PMDD showed significantly monthly absenteeism of one or more days because of premenstrual symptoms. The majority of student with PMDD had regular menstruation (89.21%) with a duration 6 days or less (85.39%) and had dysmenorrheal (92.06%) that significantly higher than that recorded to student of other categories. Only 2.94% and 1.63% of studied students practice moderate and givgorous physical activity respectively. More than one third (3.856%) of students are classified as over weight and obese and the majority (88.25%) of students are circumcised. Conclusion: the problem of premenstrual dysphonic disorders threatens menstruating females at different aspects of their life, cognitive, social, psychological and physical aspects. Recommendations: Upgrading a program for improving health related quality of life of Benha University students starting from school curriculums, school health services and development of health insurance system.