Background: Fall and pain consider a challenge for nurses in intensive care units because information of them is lacking. Aim of study: Evaluate the effect of an educational program about fall prevention and pain assessment on nurses' performance and critically ill patients' outcome. Design: A quasi experimental - design was used to accomplish the aim of this study. Setting: This study was carried out in general intensive care unit at Benha University Hospital. Sample: Convenience sample of all available nurses (65 nurses) who are working in ICU & A purposive sample of 60 patients who attended to ICU within 6 months. Tools: The following three data collection tools were used (I) Structured Questionnaire for Nurses. (II) Observational checklist regarding fall prevention and pain assessment. (III) Patients’ outcomes assessment sheet. Results: The total nurses’ knowledge & practice scores regarding fall prevention and pain assessment post educational program implementation were higher than pre implementation. Conclusion: The total nurses’ knowledge and practice pre and post implementation of educational program are significantly positively correlated. In addition, after two weeks, the study group's patient outcomes improved more than those of the control group, with statistically significant differences at (p 0.05). Recommendation: A similar study should be replicated on a large sample and other place to generalize the findings.