Background; monitoring of fluid balance activities is guides nursing interventions to achieve physiological stability. Aim; this study aims to evaluate the effect of an educational program on nurse performance regard monitoring fluid and electrolyte replacement for burned patients. Research Design: A quasi-experimental research design will be conducted to achieve the stated aim. Setting: The study will be conducted in burn department at Benha Teaching Hospital. Subjects: all nurses in mentioned sitting during the period from the beginning of July 2018 to December 2019. Tools: two tools used to collect the study data. These are structured interview questionnaire to assess nurses’ knowledge about monitoring fluid and electrolyte replacement therapy for burned patient and Observational Checklist to assess nurses practice regard monitoring fluid and electrolyte replacement therapy for burned patients Result: the result of this study showed that nearly half of nurses aged between 30≥ 40 years old, more than half of them had more than 10 years of experience and didn’t receive previous training about fluids and electrolytes replacement, the minority of nurses had good total knowledge score regarding monitoring fluid and electrolyte replacement therapy for burn patient preprogram, then increased to majority post program implementation , less than half of nurses had satisfactory practices score regarding monitoring fluids and electrolytes replacement therapy for burn patient preprogram, while increased to majority post program implementation. Also there are positive correlation between nurse’s knowledge and practice regard monitoring fluid and electrolyte replacement therapy for burned patient post program Conclusion; the current study concluded that implementation of health education program has a positive effect on improvement of the nurses’ knowledge and practices regard monitoring fluid and electrolyte replacement therapy for burned patient post program than preprogram. Recommendations: This study recommended that emphasize the importance of a continuous in- service educational program regard monitoring fluid and electrolyte replacement therapy for burned patient, Further study with replication of the current study on a larger probability sample is recommended to achieve generalization of the results and wider utilization of the designed educational program