The aim of this study is to evaluate the effect of educational program for cardiopulmonary resuscitation (CPR) using SimMan versus traditional manikin on 2nd year nursing student's performance at Medical Surgical Nursing Department laboratory- Faculty of Nursing -Benha University. Research hypothesis: The mean score of 2nd year nursing students’ performance level regarding CPR in the study group will be higher than the score of students in the control group. A quasi-experimental research design was utilized. Setting: This study was conducted in Medical Surgical Nursing Department laboratory- Faculty of Nursing -Benha University. Subject: 340 of second year nursing students were recruited in this study and divided into equal groups, the control group using the traditional manikin and a study group using SimMan. The study tools for data collection; First tool: Nursing students' self-administered questionnaire sheet. Second tool: Nursing students' practice observational checklist for CPR & AED. The results: mean scores of students' knowledge and practice regarding advanced CPR in study group was higher than control group (P