Natural products have beneficial biological activities and they also do numerous functions as drugs against cancer as well as viral and microbial infections. As a part of a program oriented towards the discovery of bioactive natural products, two wild plants (Saueda aegyptica, chenopdium murale) and 2 waste plant products (apple, banana peel) were evaluated for their antibacterial activities against Staphylococcus. aureus, Escherichia. coli and Salmonella entrica using well agar diffusion method. Phytochemical screening tests used to detect the active compounds in them. Then make serial dilution for 2 extracts (banana and Chenopodium) that showed high activity to detect MIC (Minimum Inhibitory Concentration) for E. coli of (1.562 mg /ml) in banana and (3.124 mg/ml) in Chenopodium, for Staph. aureus (6.25 mg/ml) in banana and (12.50mg/ml) in Chenopodium but MIC test was not enough, antioxidant activity test, biofilm formation and reduction, antihemoytic activity and Transmisiom Electron Microscope (TEM) tests used to confirm the presence of highly active compounds in banana and Chenopodium methanolic extracts.