Missed nursing care is a worldwide concern for nurses and nurse managers. Assessing the fundamental factors that lead to missed care activities may provide evidence that enables nurses to limit missed care and continuity of patient care. Aims: Assess missed nursing care and factors leading to missed nursing care among nurses in at selected hospitals. Design: A descriptive cross-sectional design was utilized. Setting: The study was conducted in the Intensive care Units at Menoufia University Hospital, Shebin El Kom Teaching Hospital, and Benha University Hospital. Subjects: A convenience sample of 240 nurses was taken from selected Hospitals. Tool of data collection: Missed Nursing Care Activity Questionnaire and Factors of Missed Nursing Care Questionnaire. Results: Revealed that attending interdisciplinary care conferences, health education, feeding patients, and assessment patient were the most frequent types of missed nursing care. The greatest percentages of nurses working at Shebin El Kom Teaching Hospital (41.1%) had high level missed nursing care. While the lowest percentage of nurses working at Menoufia University Hospital (21.3%) had a high level of missed nursing care. The highest total mean score for missed nursing care was 44.19±9.90 to nurses working at Shebin El Kom Teaching Hospital. The most prevalent factors of missed care were “labor resources, followed by material resources, and then communication factors. Conclusion: It is concluded that the most factor leading to missed nursing care as perceived by studied nurses were related to labor resources. The majority of studied nurses have moderate levels of missed nursing care. Recommendations: It is recommended to disseminate the study results to hospital administrators to provide them with evidence to design effective strategies that can contribute to assist in reducing missed nursing care.