Little is known about the intervention program which based on educating and training mothers of children with Attention deficit hyperactivity disorder. Although mothers of those children especially may experience stressful and difficult conditions. Aim: was to evaluate the effect of an intervention program for mothers of children with attention deficit hyperactivity disorder. Design: a quasi-experimental research was used. Setting: the psychiatric outpatient clinic at Benha University Hospital and pediatric outpatient clinic at Benha Mental Health Hospital. Sample: purposive sample involved (138) mothers with their registered children with ADHD. Tools: three tools were used for data collection: I- an interview questionnaire to gather relevant data to the study (characteristics of sample and their knowledge regarding knowledge about ADHD). II : Elcamino Pediatrics Home Version Scale to assess child's behavior adopted from The Foundation for Medical Practice Education, (2007) and III- Intervention program. Results: There were highly statistical significant differences between mothers' knowledge about attention deficit hyperactive disorders and their children's behavior post program implementation (p