Two filed experiment were conducted from Res. Expt . Cent., Fac. Agric., Moshtohor Benha. Univ. during 2005/2006 and 2006/2007 growing seasons. To study the effect of bio and mineral NPK levels(Complete strength C.S, half strength and quarter strength) and antioxidants treatments (0, Vit. C, Vit E and mixture Vit. C+E) on growth, yield and yield component and chemical composition of wheat plants Cv sakha 93.Results showed that. Studied wheat characters (i.e. growth, yield and yield component and chemical composition) were positively affected increased with increasing mineral NPK fertilizer up to CS and combination with biofertilizers in both seasons. Wheat grains soaking and spraying with Vit.C at 150 mg/l increased growth parameters, grain yield components and chemical composition in wheat plants during in both seasons. The interaction between CS mineral NPK and biofertilizer with Vit.C increased growth, yield and yield components and chemical composition of wheat plants during first and second seasons.