Chronic liver disease and its complications is a common health problem world wide. Hepatorenal syndrome (HRS type 1, 2) is one of these serious complications with high mortality. The aim of this study was to evaluate the diagnostic role of urotensin II in patients with chronic liver diseases ( both ascitic and non ascitic patients). Patients and Methods: Forty patients were selected from Gastroenterology, Hepatology and Infectious Diseases Department, Benha University Hospital, Egypt. Group (1) 20 patients with ascites (9 males and 11 females), their ages ranged from 35-65years with mean 50.95 ± 9.84. Group (2) 20 patients without ascites as a control group (8 males and 12 females) their ages ranged from 35-63 years with mean 49.25± 9.66, from the period of March 2011 to July 2011. Results : There was no statistically significant difference as regard CBC parameters ( p>0.05) between the ascitic group(1) and non ascitic group(2), except for platelet count, there was a statistically significant decrease between the 2 groups ( p