A B S T R A C T A total number of two hundred forty-one-day-old broiler chicks (Ross 308) were randomly distributed into four different treatment groups (A, B, C and D), of three replicates (20 chicks / replicate). The chicks in control group (A) were fed negative control diet, group B were fed diet containing (Nucleoforce®) (0.025%) in first 10 days of age, group B were fed diet containing (Nucleoforce®) (0.025%) in first 25 days of age. While group D was fed diet containing Nucleoforce® (0.025%) from zero day till slaughtering. This experiment was designed to investigate the effect of nucleotide as an immunostimulant for broiler chicks in terms of chick performance and economic efficiency. Results showed that, groups fed diet supplemented with Nucleoforce recorded improvements in live body weight, body weight gain and relative growth rate with no significant difference in feed intake and feed conversion index than the control group. Economic efficiency showed non-significant difference between control group and other groups but group (D) recorded high value 0.94 more than control group (A) 0.84. It was concluded that, inclusion of nucleotide 0.025% in broiler diets had a positive role in improvement of final body weight, body weight gain, feed conversion ratio and economic efficiency.