أعضاء هيئة التدريس - جامعة بنها
Decrease of serum biomarker of type II Collagen degradation (Coll2-1) by intra-articular injection of an autologous plasma-rich-platelet in patients with unilateral primary knee osteoarthritis
• 2017
معلومات البحث
المؤلفون
Rasha Mohamed Fawzy1, Nashwa Ismail Hashaad1, Amira Ibrahim Mansour2
الكلمات المفتاحية
Platelet-rich plasma, growth factors, serum coll2-1, knee osteoarthritis, Western Ontario, McMaster Universities Arthritis
Index Score
المجلة العلمية
Not Available
الناشر
Not Available
المجلد
Not Available
العدد
Not Available
الصفحات
Not Available
publication.type
International
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
Objective: This study aimed to evaluate the effect of one dose of intra-articular injection of (PRP) in the knee joint on a specific osteoarthritis
(OA) serum biomarker of cartilage degeneration, Collagen 2-1 (Coll2-1), over a short period of 3 months. The aim extended
to clarify the effect of PRP on the functional status of the osteoarthritic knee joint.
Material and Methods: Sixty patients with primary unilateral knee OA were enrolled in this study. They were subdivided according
to Kellgren-Lawrence grading scale (KL) into (Group Ι): including patients with KL grade < 3 and (Group ΙΙ): including patients with KL
grade ≥3. Patients were asked to complete the Western Ontario and McMaster Universities Arthritis Index (WOMAC) Score. PRP was
prepared and injected immediately into the affected knee. Serum Coll2-1 (S.Coll2-1) concentration was measured by enzyme-linked
immunosorbent assay (ELISA) kit pre and 3 months after PRP injection.
Results: Significant reduction in S.Coll2-1 concentration in primary knee OA patients; (p
(OA) serum biomarker of cartilage degeneration, Collagen 2-1 (Coll2-1), over a short period of 3 months. The aim extended
to clarify the effect of PRP on the functional status of the osteoarthritic knee joint.
Material and Methods: Sixty patients with primary unilateral knee OA were enrolled in this study. They were subdivided according
to Kellgren-Lawrence grading scale (KL) into (Group Ι): including patients with KL grade < 3 and (Group ΙΙ): including patients with KL
grade ≥3. Patients were asked to complete the Western Ontario and McMaster Universities Arthritis Index (WOMAC) Score. PRP was
prepared and injected immediately into the affected knee. Serum Coll2-1 (S.Coll2-1) concentration was measured by enzyme-linked
immunosorbent assay (ELISA) kit pre and 3 months after PRP injection.
Results: Significant reduction in S.Coll2-1 concentration in primary knee OA patients; (p