Staff Members - Benha University
Serum calreticulin as a novel biomarker of juvenile idiopathic arthritis disease activity
• 2017
Publication Information
Authors
Nashwa Ismail Hashaad1, Rasha Mohamed Fawzy1, Abeer Ahmed Abo Elazem2,
Mohamed Ibrahim Youssef3
Keywords
Juvenile idiopathic arthritis, calreticulin, activity score, synovitis
Journal
Not Available
Publisher
Not Available
Volume
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Issue
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Pages
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publication.type
International
Paper Link
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Supplementary Materials
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Abstract
Objective: This study aimed to investigate the relations between calreticulin (CRT) serum level and both disease activity and severity
parameters in juvenile idiopathic arthritis (JIA).
Material and Methods: In this study, 60 children with JIA and 50 age-and-sex-matched healthy subjects were enrolled. The assessment
of the disease activity was done using juvenile arthritis disease activity score 27 (JADAS-27). The assessment of disease severity
was done via gray-scale ultrasonography (US) and power Doppler US (PDUS). Enzyme-linked immunosorbent assay (ELISA) was used
to assay the serum level of human CRT.
Results: The mean serum CRT levels in JIA patients was 8.6±1.2 ng/mL and showed a highly significant increase (p=0.001) as
compared to the mean serum levels in the controls (5.02±0.77 ng/mL). There were statistically significant positive correlations
between the serum CRT levels and disease duration, tender joint count, swollen joint count, visual analog scale, erythrocyte
sedimentation rate, JADAS-27, C-reactive protein, rheumatoid factor titer, and ultrasonographic grading for synovitis and neovascularization.
Conclusion: Elevated serum CRT levels in JIA patients and its correlations with JIA disease activity and severity parameters signified
that CRT might be used as a novel biomarker for disease activity and severity in JIA.
parameters in juvenile idiopathic arthritis (JIA).
Material and Methods: In this study, 60 children with JIA and 50 age-and-sex-matched healthy subjects were enrolled. The assessment
of the disease activity was done using juvenile arthritis disease activity score 27 (JADAS-27). The assessment of disease severity
was done via gray-scale ultrasonography (US) and power Doppler US (PDUS). Enzyme-linked immunosorbent assay (ELISA) was used
to assay the serum level of human CRT.
Results: The mean serum CRT levels in JIA patients was 8.6±1.2 ng/mL and showed a highly significant increase (p=0.001) as
compared to the mean serum levels in the controls (5.02±0.77 ng/mL). There were statistically significant positive correlations
between the serum CRT levels and disease duration, tender joint count, swollen joint count, visual analog scale, erythrocyte
sedimentation rate, JADAS-27, C-reactive protein, rheumatoid factor titer, and ultrasonographic grading for synovitis and neovascularization.
Conclusion: Elevated serum CRT levels in JIA patients and its correlations with JIA disease activity and severity parameters signified
that CRT might be used as a novel biomarker for disease activity and severity in JIA.