The effect of different concentrations for both of water flae-bane leaves and mango seed plant extracts were studied especially their biological and biochemical effects on the 4th larval instar of Agrotis ipsilon using toxic baits. The results of biological studies clearly demonstrated that the tested extracts achieved significant increase in the pupal longevity and significant reduction in the larval longevity and pupal weight besides the percentage of pupation. Also, on the adult longevity for either male or female. There was remarkable significant increase in the percentage of malformation for both pupae and adults. The best treatment among all the tested extracts was water mango seed extract at 5% concentration followed by water flae-bane leaves at the same concentration. The biochemical studies proved that water mango seed extract caused increase in the secretion of both of glucsidase and Trehalse enzymes, and decease in the secretion of acetyl choline esterase. While, water flae-bane leaves extract caused increase in the secretion of acetyl choline esterase. From this point of view, may be the extracts had an effect on the rate of glucose absorption in the blood.