| publication name | Comparative immunohistochemical study of Bcl-2 and CD138 in odontogenic keratocyst, ameloblastoma, and radicular cyst, considering WHO classification |
|---|---|
| Authors | Rania G. Roshdy, Sarah N. Nasif |
| year | 2021 |
| keywords | BCL2, CD138, odontogenic keratocyst |
| journal | Egyptian Journal Of pathology |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | Local |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Background Odontogenic keratocyst (OKC) is one of the odontogenic lesions that have been recently classified as a developmental cyst in the last WHO odontogenic classification in 2017, despite its clinical aggressiveness and relative rate of recurrence. Aim The aim of the current work was to assess and compare OKC with both ameloblastoma (AM) and radicular cyst (RC) in relation to immunohistochemical expression of Bcl-2 and CD138. Materials and methods This is a retrospective study that included 15 cases of OKC, 20 cases of AM, and 15 cases of RC. Immunohistochemical technique was applied to detect and compare Bcl-2 and CD138 expressions in these lesions. Results For Bcl-2, 86.6% of the OKC cases and all studied AM cases (100%) were positive for Bcl-2, without significant statistically correlation (P>0.05). At the same time, OKCs were significantly correlated with RC, which were completely negative to Bcl- 2(P