Paroxysmal airflow blockage, airway hyper-responsiveness to irritative stimuli, wheezing, chest tightness, and coughing are all signs of asthma, a condition characterised by persistent airway inflammation. The purpose of this research was to compare the effects of an asthma exacerbation on children's blood coagulation to those of a child's stable condition. Thirty paediatric asthma patients were included in this prospective observational research. In this study, patients were split into two groups: Thirty children with asthma who were experiencing an acute flare-up made up Group 1. Group 2 included the same asthmatic kids when they were in a stable condition. Comprehensive paediatric and neurological exams, as well as determination of asthma exacerbation, asthma evaluation, laboratory work-up, measurement of protein C, determination of D-dimer, and determination of C-reactive protein were performed on all patients. The results showed that the median levels of Protein C were substantially lower during an asthma exacerbation (p=0.0001) than they were during a stable condition (range, 44-124) (range, 85-140). Exacerbation length was strongly associated with an increase in the median Protein C during an asthma exacerbation (p0.0001). D-dimer and C-reactive protein median values were also not substantially different across exacerbation durations for those with asthma. Asthma exacerbations, as shown by our research, are accompanied with considerably reduced levels of Protein C compared to normal conditions.