Background: Ethylene glycol (EG)is a colourless, odourless, sweet-tasting chemical mainly used as antifreeze which is fatal if ingested. Ginger is used as spices and as an herbal medicine (antioxidant) in Asian countries. Aim of the work: was to evaluate the protective role of Ginger against the Ethylene glycol hepato-toxicity in rats. Material and Methods: Thirty rats were divided into three equal groups: Group I (control group): GIa; 5 rats received saline and GIb; 5 rats received ginger (dose as in GIII), Group ΙΙ: were intraperitoneal injected by EG 0.75 mL for 2 consecutive days then orally administered via intra-gastric tube by EG in a daily dose of 0.1 mL /kg ethylene glycol Group ΙΙI: received EG injection with 1 mL of Ginger extract (24 mg/mL) three times weekly for 6 weeks. Blood samples were collected and livers were microscopically examined. Results: EG induced significant reduction (P=002) in Rats' BW in G II with 30% MR in comparison with GI and GIII. AST, ALT, ALK P, TBIL, and globulin levels in G II were significantly elevated (P=0.02); meanwhile there were significant decrease (P=0.03) in total protein, albumin, and A/G ratio. Microscopic examination showed: increase fibrous tissue and cellular infiltration around the portal tract in G II. Positive antioxidant effect of Ginger over the EG toxicity in G III by apparent decrease of fibrosis, cellular infiltration, vacuolation and necrosis of hepatocytes. Some hepatic lobules regained their normal architecture with proliferated bile ductules. Conclusions: Ginger might be more effective in amelioration of ethylene glycol induced hepato-toxicity.