Abstract Salicylic acid (SA) and polyamines (PA) are widely used to overcome various abiotic stresses including salt (NaCl) stress in plants. In the present investigation, co-application efficacies of SA and PA on the salt stress in the form of NaCl (200 mM) were evaluated in Lycopersicon esculentum. After transplantation, at 10-d stage, seedlings were exposed to NaCl through soil and then allowed to grow till 30-d stage and at 31-d stage of growth, plants were sprayed with double distilled water (control) or spermidine (1.0 mM) and/or SA (10–5 M). The salt stress significantly reduced the growth, gasexchange parameters, but increased antioxidant enzyme and proline content in the leaves. Moreover, the loss caused by salt stress was successfully restored by the following treatment of spermidine and salicylic acid.