This study was to investigate the changes of physiological and anatomical in tomato plants infected with tomato yellow leaf curl virus (TYLCV) isolate. it was found the growth characteristic, cell membrane stability index, photosynthetic pigment, carbohydrate contents and related to mineral ions contents of tomato plants. As were decreased, when compared with healthy plants. While electrical leakage increased than healthy plants. The mesophyll cells of infected tomato plants appeared relatively small or without intercellular spaces the .