To estimate serum Adropin (ADR) and Adipose fatty-acidbinding
proteins (AFABP) levels at 6th wk and its relations with insulin
resistance (IR) judged by homeostasis model assessment of IR
(HOMA-IR) score and their predictive value for later development of
gestational diabetes mellitus (GDM).
Patients & Methods: 335 pregnant women gave blood samples for
estimation of fasting blood glucose (FBG), and fasting serum insulin,
ADR and AFABP. All women underwent the 75-Oral glucose tolerance
test (OGTT) and HOMA-IR scoring at 6th and 24th week GA.
Results: At 6th wk GA, 77 women had IR score >2 and 24th wk 39
women developed GDM and 106 had IR >2. Mean 6th wk serum ADR
levels were significantly lower, while serum AFABP levels were
significantly higher in GDM than non-GDM women. Statistical
analyses defined 6th wk GA high serum AFABP and insulin, BMI and
2-hr PPBG, and low serum ADR, as significant predictors for
development of IR at the 24th wk GA.
Conclusion: Pregnancy induces maternal IR that was related to
maternal BMI and may progress to GDM that was reported by a
frequency of 11.9%. Development of GDM and IR were closely related
to high serum AFABP and low serum ADR levels.