Staff Members - Benha University
SERUM ADROPIN AND ADIPOSE FATTY-ACID BINDING PROTEIN AT 6TH WEEK OF PREGNANCY ARE SIGNIFICANT PREDICTORS FOR DEVELOPMENT OF INSULIN RESISTANCE AT THE 24TH WEEK.
• 2018
Publication Information
Authors
Amr Sharafeldeen MD1 and Raafat R. Mohammed MD2
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publication.type
International
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Abstract
To estimate serum Adropin (ADR) and Adipose fatty-acidbinding
proteins (AFABP) levels at 6th wk and its relations with insulin
resistance (IR) judged by homeostasis model assessment of IR
(HOMA-IR) score and their predictive value for later development of
gestational diabetes mellitus (GDM).
Patients & Methods: 335 pregnant women gave blood samples for
estimation of fasting blood glucose (FBG), and fasting serum insulin,
ADR and AFABP. All women underwent the 75-Oral glucose tolerance
test (OGTT) and HOMA-IR scoring at 6th and 24th week GA.
Results: At 6th wk GA, 77 women had IR score >2 and 24th wk 39
women developed GDM and 106 had IR >2. Mean 6th wk serum ADR
levels were significantly lower, while serum AFABP levels were
significantly higher in GDM than non-GDM women. Statistical
analyses defined 6th wk GA high serum AFABP and insulin, BMI and
2-hr PPBG, and low serum ADR, as significant predictors for
development of IR at the 24th wk GA.
Conclusion: Pregnancy induces maternal IR that was related to
maternal BMI and may progress to GDM that was reported by a
frequency of 11.9%. Development of GDM and IR were closely related
to high serum AFABP and low serum ADR levels.
proteins (AFABP) levels at 6th wk and its relations with insulin
resistance (IR) judged by homeostasis model assessment of IR
(HOMA-IR) score and their predictive value for later development of
gestational diabetes mellitus (GDM).
Patients & Methods: 335 pregnant women gave blood samples for
estimation of fasting blood glucose (FBG), and fasting serum insulin,
ADR and AFABP. All women underwent the 75-Oral glucose tolerance
test (OGTT) and HOMA-IR scoring at 6th and 24th week GA.
Results: At 6th wk GA, 77 women had IR score >2 and 24th wk 39
women developed GDM and 106 had IR >2. Mean 6th wk serum ADR
levels were significantly lower, while serum AFABP levels were
significantly higher in GDM than non-GDM women. Statistical
analyses defined 6th wk GA high serum AFABP and insulin, BMI and
2-hr PPBG, and low serum ADR, as significant predictors for
development of IR at the 24th wk GA.
Conclusion: Pregnancy induces maternal IR that was related to
maternal BMI and may progress to GDM that was reported by a
frequency of 11.9%. Development of GDM and IR were closely related
to high serum AFABP and low serum ADR levels.