Staff Members - Benha University
Validity of Doppler subclinical synovitis as an activity marker associated with bone erosions in rheumatoid arthritis patients during clinical remission
egyptian journal of radiology and nuclear medicine • 2016
Publication Information
Authors
Tohamy H Elkhouly ; Basant M Elnady
Keywords
Rheumatoid arthritis (RA), musculoskeletal ultrasonography (MSUS), gray scale (GS), color Doppler (CD), disease modifying anti-rheumatic drugs (DMARDs).
Journal
egyptian journal of radiology and nuclear medicine
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Introduction: Clinical remission is a realistic goal in rheumatoid arthritis (RA) patients. Doppler signals-synovitis may also considered predictive of clinical flare-ups in RA. Objective: The aim of this study to detect subclinical synovitis and erosions by musculoskeletal ultrasound (MSUS) in RA patients with clinical remission and free from physical synovitis.
Materials and Methods: 41 RA patients were studied who achieved clinical remission for at least 6 months proved by clinical disease activity index (CDAI) and DAS28 without tender neither swollen joints. MSUS of 22 joint done for each patient, the data of gray scale (GS) and color Doppler (CD) graded on a semi-quantitative scale from 0 to 3.
Results: The percentage of RA patients with subclinical synovitis present in at least one joint with CD≥ 1, and CD≥ 2 were 70.7% and 29.2% respectively. The results of CD were significantly lower regarding the use of biologic agents compared to patients on conventional disease modifying anti-rheumatic drugs (DMARDs) alone (p=0.01). There was a strong association between CD synovitis and MSUS bone erosions (p
Materials and Methods: 41 RA patients were studied who achieved clinical remission for at least 6 months proved by clinical disease activity index (CDAI) and DAS28 without tender neither swollen joints. MSUS of 22 joint done for each patient, the data of gray scale (GS) and color Doppler (CD) graded on a semi-quantitative scale from 0 to 3.
Results: The percentage of RA patients with subclinical synovitis present in at least one joint with CD≥ 1, and CD≥ 2 were 70.7% and 29.2% respectively. The results of CD were significantly lower regarding the use of biologic agents compared to patients on conventional disease modifying anti-rheumatic drugs (DMARDs) alone (p=0.01). There was a strong association between CD synovitis and MSUS bone erosions (p